1. Quick Detail:
| CAS No.: |
4418-61-5 |
Other Names: |
5-Amino-1H-tetrazole |
MF: |
CH3N5 |
EINECS No.: |
224-581-7 |
Place of Origin: |
China (Mainland) |
Type: |
Syntheses Material Intermediates |
Purity: |
99% min |
Application: |
used in organic synthesizing intermediate |
Appearance: |
White crystalline |
2. Description:
Tetrazole is one of a class of organic heterocyclic compounds containing a five-membered diunsaturated ring structure composed of four nitrogen atoms and one carbon atom. The simplest member of the tetrazole family is tetrazole itself, white to pale yellow crystalline solids with a weak characteristic odor; soluble in water and alcohol, melts at 156 C. Tetrazole is explosive. It is used as a gas generating agent for air bags. Shipment of tetrazole is available only as a solution in some countries. Tetrazole and its derivatives are used for biological activities such as antiviral, antibacterial, antifungal and antituberculous. They are used as catalysts in the synthesis of phosphonates.
Oligonucleotide is a short DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) sequence, typically made up of a few (2-20) covalently linked nucleotides. In molecular genetics, a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe for detecting complementary DNA or RNA. Oligonucleotides are currently used for genomic,proteomic and drug discovery technologies. Tetrazole is the traditional oligonucleotide synthesis activato for good coupling efficiency and to decrease the coupling times. But there are disadvantages of tetrazole; crystallisation problem from solution and potential explosive property at room temperature. Some alternatives have been recommended;
5-Ethylthio-1H-tetrazole [CAS RN: 89797-68-2]
5-Methylthio-1H-tetrazole [CAS RN: 29515-99-9]
5-Benzylthio-1H-tetrazole [CAS RN: 21871-47-6]
5-Nitrophenyl-1H-tetrazole
4,5-Dicyanoimidazole [CAS RN: 1122-28-7]
5-Aminotetrazole is used as an intermediate for manufacturing organic compounds. It is used as a gas generator (nitogen) and used in air bag.
3. Applications:
There are several pharmaceutical agents which are tetrazoles. The tetrazole ring can act as a bioisostere for thecarboxylate group. Angiotensin II receptor blockers, in particular, such as losartan and candesartan, often contain tetrazoles.
A well-known tetrazole is dimethyl thiazolyl diphenyl tetrazolium salt (MTT). This tetrazole is used in the MTT assay to quantify the respiratory activity of live cells in cell culture, although it generally kills the cells in the process. Tetrazole's derivatives can also be used in DNA synthesis.
Some tetrazole derivatives with high energy have been investigated as high performance explosives as a replacement forTNT and also for use in high performance solid rocket propellant formulations.
Other tetrazoles are used for their explosive or combustive properties, such as tetrazole itself and 5-aminotetrazole, which are sometimes used as a component of gas generators in automobile airbags. Tetrazole based energetic materials produce high-temperature, non-toxic reaction products such as water and nitrogen gas,and have a high burn rate and relative stability,all of which are desirable properties. The delocalization energy in tetrazole is 209 kJ/mol.
4. Specifications:
Product name |
5-Aminotetrazole |
Synonyms |
1H-Tetrazol-5-amine
5-Amino-1H-tetrazole
Tetrazol-5-ylamine |
CAS No. |
26628-22-8 |
EINECS |
224-581-7 |
Molecular formula |
CH3N5 |
Molecular weight |
85.07 |
Appearance |
White crystalline powder |
Melting point |
200-206 ºC |
Assay |
99%min |
Moisture |
0.5%Max |
Packing |
25Kg/drum |
Application |
Intermediates in organic synthesis
|
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