Camptotheca Acuminata Extract/Camptothecin of 98% 10-Hydroxycamptothecin Camptothecin (CPT)

Camptothecin is a plant secondary metabolite used as an anti-cancer drug that damages DNA, leading to the destruction of the cell. It comes from Camptotheca acuminata, a deciduous tree found in southern China. A close analogue, 9-methoxycamptothecin, is also present in the same source

 

10-Hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate (a tree native to mainland China). is a kind of pharmaceutical intermediate, an alkaloid originally isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase (Topo )[1]and has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELC and HL-60cells.

10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity. Compared with camptothecin (CPT), 10-Hydroxycamptothecin has a longer-lived cleavable complex, and is substantially more cytotoxic against cancer cells, indicating that the persistence of cleavable complexes may be an essential property for increasing the likelihood of a collision between the replication fork and a cleavable complex, giving rise to lethal DNA lesions. [1]10-Hydroxycamptotheci treatment significantly inhibits angiogenesis both in vitro and in vivo at relatively low concentrations, and this effect is related with induction of apoptosis in human microvascular endothelial cells (HMEC). 10-Hydroxycamptothecin significantly represses the proliferation of Colo 205 cells at a relatively low concentration (5-20 nM). 10-Hydroxycamptothecin treatment induces Colo 205 cells arrested in the G2 phase, and triggers caspase-3-dependent apoptosis. Consistently, oral administration of 10-Hydroxycamptothecin at a relatively low dose is able to inhibit the growth of Colo 205 xenografts in mice.

     Camptothecine

    CAS#: 7689-03-4

    Other names: Camptotheca Acuminata Decne Extract

     Botanical Source: Nothapodytes pittosporoides (Oliv.) Sleum

    Specifications: Camptothecine 96%,98%,99% min. By HPLC


   Product name: 10-hydroxycamptothecin

     Active ingredient:10-hydroxycamptothecin

    Botanical source: Camptotheca acuminata Decne

    Part of the plant used:Seed

     Specification:95% 98% 99%

     Molecular formula:C20H16N2O5

     Molecular Weight: 364.35

      Appearance:Light Yellow Crystal powder

      Extract method: alcohol

     Test method: HPLC

    Solubility:slightly soluble in alcohol

   Usage: Pharmaceuticals, healthcares

1.Natural camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

2.In clinical camptothecin is widely believed that natural camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, camptothecin is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, camptothecin ultimately causes cell death.

3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.

4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

Packing: 1kg/bag,5kg/bag,or 25kg/Hardboard drum,or at your requirment.

1KG : Double pharma-grade polybag inside,sealed Aluminum foil bag outside;
5KG : Double pharma-grade polybag inside,Hardboard cartons outside;
25KG: Double pharma-grade polybag inside,Hardboard drum outside.

Drum size: 38CM*38CM*51CM/25kg , Drum Net Weight: 1.5KG
Carton size: According to the Qty.

Shipping: By TNT/DHL/EMS/FedEx or by Air/ Sea as per Qty.

Shelf Life: 24 months when properly stored.
Storage: Store in Cool and dry place,keep away from strong light,hight temperature.